Early Antibiotic Treatment for Pediatric Febrile Urinary Tract Infection and Renal Scarring

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Risk Factors for Recurrent Urinary Tract Infection and Renal Scarring.

OBJECTIVES To identify risk factors for recurrent urinary tract infection (UTI) and renal scarring in children who have had 1 or 2 febrile or symptomatic UTIs and received no antimicrobial prophylaxis. METHODS This 2-year, multisite prospective cohort study included 305 children aged 2 to 71 months with vesicoureteral reflux (VUR) receiving placebo in the RIVUR (Randomized Intervention for Ve...

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Antibiotic Prophylaxis for Urinary Tract Infection-Related Renal Scarring: A Systematic Review.

CONTEXT Acute pyelonephritis may result in renal scarring. Recent prospective studies have shown a small benefit of antibiotic prophylaxis in preventing symptomatic and febrile urinary tract infections (UTIs), while being underpowered to detect any influence in prevention of renal damage. OBJECTIVES Review of the literature and a meta-analysis to evaluate the effect of antibiotic prophylaxis ...

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Early dimercaptosuccinic acid renal scan in children with first febrile urinary tract infection.

OBJECTIVE To determine use of early Tc-99m dimercaptosuccinic acid scintigraphy in screening for vesicoureteral reflux following first febrile urinary tract infection. METHODS 43 children (1 mo-5 yr) with first febrile urinary tract infection underwent micturating cystourethrography, abdominal sonogram and early dimercaptosuccinic acid scintigraphy. RESULTS Early dimercaptosuccinic acid sci...

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Chemokine response to febrile urinary tract infection.

BACKGROUND Mucosal CXC chemokines recruit inflammatory cells to the infected urinary tract. The chemokine response repertoire of the urinary tract and the relationship to disease severity have not been examined, however. METHODS This study quantified CXC (CXCL1, CXCL3, CXCL5, CXCL8, CXCL9, and CXCL10) and CC (CCL2, CCL4, and CCL5) chemokines in sequential urine samples obtained from 50 patien...

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Issues in febrile urinary tract infection management.

Urinary tract infections are common occurrences in the pediatric age group and are a cause of significant morbidity and expense. The understanding of the consequences and sequelae of febrile urinary tract infections led to revision of standard protocols initiated by the American Academy of Pediatrics (AAP) in 1999. A less invasive protocol of radiologic evaluation has been the major outcome of ...

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ژورنال

عنوان ژورنال: JAMA Pediatrics

سال: 2016

ISSN: 2168-6203

DOI: 10.1001/jamapediatrics.2016.1181